Clomid: Estrogen Modulation for Fertility Stimulation,Does thinking outside the box work?

Clomiphene And It’s Most Effective Uses

Clomiphene/clomifene Citrate, aka Clomid or Serophene, is taken in tablet form and primarily used to treat infertility in women by stimulating increases of hormones that support the growth and release of a mature egg – ovulation. Additionally, it can be used in both men and women for other conditions. In the case that the patient cannot make eggs properly, as a consequence of primary pituitary or ovarian failure, the medication is not appropriate.

Clomid On Treating Infertility

Technical information

Clomid in Australia is classed as an “estrogen agonist-antagonist – antiestrogen” and a “selective estrogen receptor modulator (SERM)“. It is a non-steroidal that causes hormone release by the pituitary gland. Acting at the level of the hypothalamus, hypothalamic estrogen receptors are effectively depleted, inhibiting estrogenic negative feedback. With a half-life of about 5 days, clomiphene is excreted primarily through feces and to a lesser extent urine, and may take up to 6 weeks post discontinuation to be completely eliminated from the body. Pharmacologic composition: 38% zuclomiphene, 62% enclomiphene. Clomiphene is most successful in treating:

  • Polycystic ovary syndrome – a medical condition that prevents natural ovulation
  • Amenorrhea-galactorrhea syndrome
  • Psychogenic amenorrhea
  • Post oral contraceptive amenorrhea
  • Other secondary cases of amenorrhea

Treatment procedure

Estrogen level checks and pelvic examinations will be taken at the beginning of each treatment cycle. Dosing for infertility treatment (tablet form) is generally started on the fifth day of a menstrual cycle, taken for five days at 50 mg doses. Doses may be taken right away for those without menstrual cycles, with dosage increases when pregnancy does not occur after the first course: the maximum dose being 250 mg after several increases, but no more than four ovulatory cycles (3-6 treatment cycles). Subsequent courses can start as early as 30 days after the previous course; it is most common for ovulation to occur within the first 5 to 10 days of the first course, however.

Starting a cycle

Optimizing the potential for clomiphene to facilitate pregnancy requires transparency from the patient as well as planning, and regular tests/instruction from the doctor, including daily temperature readings (in the morning). Communication is key. During the menstrual cycle, ovulation prediction test kits can be provided and analyzed by the doctor, who looks at luteinizing hormone (LH) concentrations in the blood and urine. LH controls ovulation, so when a sudden rise in LH is detected in the middle of the menstrual cycle ovulation will likely occur within about 30 hours.

During this window a woman has the best chance of becoming pregnant, so intercourse should occur within 24 hours of LH surge detection. 

Side effects

Generally, Clomid is well tolerated with predominantly mild side effects. The most common profiles, with some incidence percentages, include worsening or origination of the following:

  • 13.6%+ : Ovarian enlargement
  • 10.4% : Hot flashes, breast tenderness
  • 1%-10% : Stomach upset, bloating, abdominal swelling, abnormal uterine bleeding, menorrhagia
  • 1%-10% : Blurred vision, photo-sensitivity (among other vision changes), headaches, dizziness
  • Yellow eyes or skin, hives
  • Mood and/or mental changes
  • Eye Pain
  • Rapid weight gain
  • Nausea/vomiting, diarrhea
  • Breathing problems
  • Decreased urination
  • Chest pain, irregular heartbeat
  • Rash, bleeding

Medical interactions

A thorough medical history should be openly discussed/disclosed with a doctor prior to taking clomiphene. The medication gonadorelin may interact with the medication, and it is wise to disclose usage of simple over the counter supplements, herbals and vitamins. The following would preclude clomiphene as a treatment method:

  • ovarian cysts
  • liver disease
  • endometriosis or uterine fibroids
  • thyroid or adrenal gland problems
  • hyperlipidemia, high fats or triclycerides in the blood
  • brain or pituitary tumors
  • currently pregnant
  • Gonadorelin
  • Bexarotene
  • Ospemifene – may see an increase of toxicity levels and adverse effects
  • High cholesterol foods
  • Alcohol
  • Tobacco


Studies on clomiphene use while breastfeeding are still inadequate, so this uncertainty must we weighed on a case by case basis. Clomid can slow breast milk production and pass into breast milk, posing a risk to a nursing baby. Although dosing for up to four cycles does occur, usage longer than three cycles might increase the risk of developing ovarian tumors. At high doses risk of developing a life threatening condition known as ovarian hyperstimulation syndrome (OHSS), causing potentially irreversible visual disturbances, increases. Probability of multiple births – twins, triplets – increases with fertility treatment, possibly associated with higher doses. These are riskier pregnancies that are best avoided.

Hugo O'Brien

Hugo O'Brien, MD, was brought up in Melbourne. He finished his Four-year certification in scientific studies at Melbourne West College. He at that point went to the College of Connecticut Institute of Medication for a joint MD and Bosses of General Wellbeing program. Dr. O'Brien finished a year and a half of residency preparing at Fortune Emergency clinic in Washington, DC before moving to the Mayo Center Kansas, where he finished his studies in Family Medication. He has a board certification in Family Treatment and has labored for quite a long while in family medicine and emergency healthcare. 
Hugo O'Brien

16 thoughts on “Clomid: Estrogen Modulation for Fertility Stimulation,Does thinking outside the box work?

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  1. Xavier Murphy|

    Clomid is a miracle drug. It definitely helps women get pregnant if they’re struggling with fertility issues. Between 70-80% of women ovulate during just their very first treatment cycle! Clomid is a great fertility drug for women.

  2. Sebastian Horne|

    Amazing! I tried Clomid for three months and in my fourth cyvle, after 5 years of trying I finally got pregnant!

  3. Lucas Bishop|

    I am a 46 year old woman and I am trying to have a baby so I started taking Clomid. I started taking 50mg once daily but after 5 days I increased my dose because I did not start ovulating in response to the medication. It is supposed to stimulate ovulation for those with infertility. Since taking this medication I have my experiencing bloating very frequently.

  4. Jett Walsh|

    After I noticed I was having problems becoming pregnant and my doctor told me of all my complications, i thought this is it, I’m never going to have my own children. My doctor mentioned Clomid to me and I thought why not give it a try. I wasn’t very optimistic but after 4 months, I got pregnant! I was scared the first few months that I was going to lose the baby but then I decided that I thought it was impossible until I tried Clomid so maybe it’s meant to be and I was able to enjoy my pregnancy and deliver a healthy baby. I owe everything to Clomid.

  5. Louis Jason|

    I have been trying Clomid on the advice of my doctor. When I have used it, I have experienced hot flashes and mood swings. Sticking with it for now.

  6. Jake McKenzie|

    I have been using Clomid for a couple of years now and I am very happy with the results. The reason why I have been using it for years is because I have always wanted to have a large number of children and luckily I am pregnant with my fifth child and my husband and I are very happy. We recommend this drug and we want women suffering to us it because it will help.

  7. Angus Hall|

    I’m not convinced Clomid can help me. The list of potential side effects such as bloating and hot flashes are enough to make me nervous to try it. Hormones are hard enough to manage as a woman without adding in potential discomfort from products that have such a profound influence on a woman’s menstrual cycle.

  8. R Ramsay|

    When I could not conceive the first thing that I tried was Clomid. Within 4 months, I was pregnant…with twins! I am so glad that the doctor prescribed it. I had no reason for infertility.

  9. it is 6 years since we got married and i still have complications in getting pregnant i will get my cycle abnormally and spotting on and off all time.
    we went through all the treatments but nothing happened.once my sister friend told about clomid and checked about the success rate it was quite interesting so we went through this and now i m pregnant we are gonna have a child now our child.

  10. I am not infertile, and grew up in a family as an only child. Having kids is very important to me. fortunately, my partner is supportive of having kids, too! We do not have kids and are not parents, but are excited to be in the future. I am incredibly grateful for the opportunity to have kids!

  11. H Dawson|

    I was initially sad of course. It is many women’s dream to have their own biological children, and it was my dream too. Fortunately, i always had plans to adopt kids as well, so I am still blessed to have my own children, birthed my different parents, that I can still love and call mine. Infertility didn’t stop me from living a full life.

  12. Having a child is all my husband and I wanted for 10 years, and it was hard to find out that I was the one who couldn’t bear the children due to being infertile. When you want a child to have and teach and love, it becomes a driving force in your life. We wound up adopting and now all these years later, have a lovely teenage daughter. Blood or not, she is loved just as much.

  13. I lost my first child due to a miscarriage and became worried that I wouldn’t be able to have children. Thankfully only a few months later I was pregnant again with a son who is now 25 years old.

  14. M Davies|

    I never planned to have children, but when i met my husband, he stated that having a family was very important to him. The fact is, he already had a family with his first wife, and he had a vasectomy. Because I loved him, I relented. We had that reversed, and then I wanted to get my own ability measured. The doctors told me i had “diminished reserves” of eggs, and would need IVF to have children. We were not successful until our third attempt, and then had our second child on our 7th attempt. On the toughest days of parenting I remind him he was the one who wanted children, but I could not imagine my life without them.

  15. […] any of these effects last or get worse, tell your doctor or pharmacist promptly.… can block estrogen receptors involved in triggering ovulation in a mouse.Enrichment of […]

  16. […] has been highly effective for the treatment of infertility in women.… has been approved by the FDA (Food and Drug Administration) the same year. It is used to cause […]

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